Traditional Uses:
- Wound healing and skin regeneration
- Circulatory improvement and vein health
- Cognitive enhancement
- Anxiety and stress reduction
- Collagen production support
Scientific Evidence:
- Wound Healing:
- Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2013). Centella asiatica in cosmetology. Postępy Dermatologii i Alergologii, 30(1), 46-49. https://doi.org/10.5114/pdia.2013.33378
- Review documenting increased collagen synthesis, angiogenesis, and epithelialization in wounds treated with Centella extracts or its triterpenes.
- Vein Health:
- Cesarone, M.R., Belcaro, G., De Sanctis, M.T., Incandela, L., Cacchio, M., Bavera, P., Ippolito, E., Bucci, M., Griffin, M., Geroulakos, G., Dugall, M., Cseri, J., & Cacchio, M. (2001). Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. Angiology, 52(2 Suppl), S15-S18. https://doi.org/10.1177/000331970105200204
- Clinical research showing improvements in microcirculation parameters and reduction in capillary filtration in patients with venous hypertension.
- Cognitive Function:
- Soumyanath, A., Zhong, Y.P., Gold, S.A., Yu, X., Koop, D.R., Bourdette, D., & Gold, B.G. (2005). Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. Journal of Pharmacy and Pharmacology, 57(9), 1221-1229. https://doi.org/10.1211/jpp.57.9.0018
- Research demonstrating neuroprotective effects and support for nerve regeneration, underpinning cognitive benefits.
- Anxiety Reduction:
- Jana, U., Sur, T.K., Maity, L.N., Debnath, P.K., & Bhattacharyya, D. (2010). A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Medical College Journal, 12(1), 8-11.
- Study showing significant improvements in anxiety scores, stress levels, and mental fatigue in patients with generalized anxiety disorder taking Centella extract.
- Skin Health and Collagen:
- Lee, J., Jung, E., Kim, Y., Park, J., Park, J., Hong, S., Kim, J., Hyun, C., Kim, Y.S., & Park, D. (2006). Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Medica, 72(4), 324-328. https://doi.org/10.1055/s-2005-916227
- Research identifying asiaticoside as a key compound stimulating collagen synthesis through specific cellular pathways, explaining Centella’s benefits for skin health.
